Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway. NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :) Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway. If you found this video helpful, please like and subscribe for more videos :) JJ *Subscribe for more free medical lessons* /channel/UCFPvnkCZbHfBvV8ApBBE0vA ------------------------------------------------------------------------------------------------------------- Try Audible and Get A Free Audiobook https://www.amazon.com/dp/B00NB86OYE/?_encoding=UTF8&ref_=sv_adbl_subnav_ref1_1 For books and more information on these topics https://www.amazon.com/shop/jjmedicine Please help support this channel and future lessons by becoming a patron (and get cool stuff) ➜ https://www.patreon.com/jjmedicine Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/ Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1: /watch/guNo9E2hW40ho Fatty Acid Synthesis Pathway: /watch/ozMNpL_SQuWSN Wnt/B Catenin Signaling Pathway: /watch/sgpj9J4PVGNPj Upper vs. Lower Motor Neuron Lesions: /watch/gn35V47dNtid5 Lesson on the Purine Synthesis and Salvage Pathway: /watch/kkA8IvVFK2eF8 Gastrulation | Formation of Germ Layers: /watch/4JCES0nkK6dkE Introductory lesson on Autophagy (Macroautophagy): /watch/Ay5cHzKVSmUVc Infectious Disease Playlist /playlist/PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b Dermatology Playlist /playlist/PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW Pharmacology Playlist /playlist/PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR Hematology Playlist /playlist/PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju Rheumatology Playlist /playlist/PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle Endocrinology Playlist /playlist/PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP Nephrology Playlist /playlist/PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8 ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

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